A longevity supplement protocol grounded in evidence looks different from most anti-ageing stacks. The goal is not to override biological ageing but to support the cellular mechanisms known to decline with age, specifically NAD+ availability, sirtuin activity, and senescent cell accumulation. This protocol covers the AE·ORA RENEW system and the lifestyle practices that amplify it.
Daily NAD+ Foundation
NAD+ Capsules (AEORA-RENEW-NAD-60): 2 capsules with breakfast. NAD+ 500mg provides the direct cofactor. Quercetin 250mg inhibits CD38 (the enzyme that degrades NAD+) and has senolytic properties. Resveratrol 150mg at 98% purity activates SIRT1 and SIRT3 downstream. Taking with food reduces nausea risk at high NAD+ doses.
Cycling NMN for Deeper Restoration
NMN Capsules (AEORA-RENEW-NMN-30): 1 capsule in the morning on an empty stomach. NMN is most efficiently absorbed without food-derived amino acids competing for transporter access. Use NMN in monthly cycles alongside NAD+ or alternate monthly between them depending on budget and individual response.
Lifestyle Amplifiers
Intermittent fasting activates SIRT1 through AMPK signalling, additive to the NAD+-sirtuin pathway (Cell Metabolism). Resistance training upregulates NAMPT, the rate-limiting enzyme in the NAD+ salvage pathway. Cold exposure activates SIRT3 in mitochondrial tissue. These are not optional additions; they are the primary drivers that the protocol amplifies.
Realistic Expectations
These supplements support the cellular mechanisms of healthy ageing. They do not reverse ageing. Sleep deprivation, chronic stress, and poor diet each independently accelerate the NAD+ decline these products address. The protocol works best as a complement to, not a replacement for, sleep quality, exercise, and nutrition.
Frequently Asked Questions
Quick answers to the questions readers most often ask.
What supplements are best for longevity?
The strongest evidence for longevity supplementation centres on NAD+ precursors (NMN, NR), sirtuin activators (resveratrol), senolytics (quercetin), and compounds that support mitochondrial function. All are included in the AE·ORA RENEW range. Omega-3, vitamin D, and magnesium also have strong evidence bases for long-term health.
Should I take NMN or NAD+ for longevity?
Both are valid options. NMN is a more direct NAD+ precursor with strong human trial evidence. NAD+ formulations can include complementary compounds like quercetin (CD38 inhibitor) and resveratrol (sirtuin activator). A combined approach using both is more comprehensive but requires a larger investment.
Does resveratrol actually work for longevity?
Resveratrol activates SIRT1 and SIRT3, sirtuins involved in gene expression regulation, mitochondrial biogenesis, and cellular stress resistance. Animal and in vitro evidence is strong. Human evidence is more limited in scale but consistent with the mechanism. Research in Nature confirmed resveratrol's sirtuin activation requires NAD+ as a cofactor, supporting the combination approach.
What does quercetin do in a longevity supplement?
Quercetin has two relevant mechanisms: it inhibits CD38 (the enzyme responsible for NAD+ degradation, which increases with age and inflammation), and it has senolytic properties (selectively clearing senescent cells that contribute to chronic inflammation). Both mechanisms are relevant to the longevity context.
When is the best time to take NAD+ supplements?
Most protocols recommend taking NAD+ and NMN supplements in the morning, with or without food depending on the formulation. Morning timing aligns with the natural circadian rhythm of NAD+ metabolism and avoids the mild sleep-disrupting effect that high-dose NAD+ can cause in some individuals when taken in the evening.
References
This article references peer-reviewed clinical research. Click through to read the source studies on PubMed.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
