The dose matters.
The research is non-negotiable.
Most supplements are formulated around label appeal, a long ingredient list at sub-therapeutic doses. AE·ORA is built the other way. We start with the peer-reviewed dose, then build the product around it.
Every AE·ORA formula is anchored to a published randomised controlled trial or systematic review. The dose in the capsule matches the dose tested in the study. Not approximately. Exactly.
Why most supplements
don't work at all
The supplement industry has a dose problem. A product can legally include an ingredient at any amount and feature it prominently on the label. Most do exactly that. Label sophistication has no relationship to clinical efficacy.
The research is clear: the therapeutic effect of magnesium glycinate, ashwagandha, Lion's Mane, NAD+ and NMN is dose-dependent. At sub-threshold doses, there is no meaningful physiological effect. At the research-validated dose, outcomes are reproducible and statistically significant.
AE·ORA was built on one constraint: match the dose that the evidence supports, or don't include the ingredient at all. REST. RISE. RENEW. Each ingredient anchored to its peer-reviewed dose. Nothing else.
Peer-reviewed dose anchoring
Every dose is drawn from a published RCT or position stand. The exact dose. Not 'inspired by', the same number.
Single-pathway ingredients
REST, RISE and RENEW formulas use ingredients that work through distinct biological mechanisms. No overlap. No competition. Full-dose synergy.
Branded forms only
KSM-66, standardised extracts and pharmaceutical-grade actives, not commodity powders. Branded extracts are standardised to the concentration used in the trials that validated them.
Verified at batch level
Every batch third-party tested. Identity, potency, heavy metals, microbial. COA on file for every batch.
Glycinate Bisglycinate · Chelated magnesium · Mg(C₂H₄NO₂)₂
The most bioavailable form of magnesium for sleep architecture and overnight muscle recovery. Works through GABA receptor activation, not sedation.
Matching Abbasi et al. 2012, the RCT establishing this as the effective dose for insomnia severity improvement
**GABA receptor co-activation.** Magnesium acts as a natural NMDA receptor antagonist and potentiates GABA activity, the brain's primary inhibitory neurotransmitter, reducing neural excitability before sleep onset.
**Melatonin synthesis support.** Magnesium is a required cofactor in the enzymatic conversion of serotonin to melatonin. Deficiency directly suppresses endogenous melatonin production.
**HPA axis modulation.** Magnesium suppresses ACTH and cortisol release from the adrenal axis, reducing the evening cortisol that prevents sleep onset.
**Glycinate bioavailability.** Absorbed via amino acid transporters, not saturable mineral channels, achieving 80–90% absorption vs 20–30% for oxide forms.
The majority of magnesium supplements use magnesium oxide, the cheapest form, with absorption rates below 4%. At a nominally high dose of 400mg oxide, the elemental magnesium actually absorbed may be less than 16mg.
Glycinate chelation uses amino acid transporters that don't saturate at higher doses, achieving 80–90% absorption. 275mg elemental in glycinate form delivers more absorbed magnesium than 600mg in oxide form.
The Abbasi et al. 2012 RCT used glycinate specifically. The outcomes documented, ISI score reduction, sleep efficiency improvement, sleep onset latency decrease, are properties of the glycinate form at the correct dose.
The effect of magnesium supplementation on primary insomnia in elderly
Double-blind RCT. 46 participants. ISI score, sleep efficiency, sleep onset latency all significantly improved vs placebo.
RCT
The effect of magnesium supplementation on primary insomnia in elderly
Double-blind RCT. 46 participants. ISI score, sleep efficiency, sleep onset latency all significantly improved vs placebo.
Dose: 500mg magnesium (~250mg elemental) for 8 weeks.
ISI score: 12.76 → 8.40 (p < 0.001). Sleep efficiency: 73.88% → 79.66%. Sleep onset latency: 22.35 → 14.28 min.
Serum melatonin increased; serum cortisol significantly decreased.
PMID: 23853635 · J Res Med Sci 2012;17(12):1161-9
Oral Mg supplementation reverses age-related decrease in deep and slow wave sleep
Reversed age-related decline in slow wave sleep, the deep sleep stage critical for memory consolidation and recovery.
RCT
Oral Mg supplementation reverses age-related decrease in deep and slow wave sleep
Reversed age-related decline in slow wave sleep, the deep sleep stage critical for memory consolidation and recovery.
Slow wave sleep percentage increased significantly (p = 0.04). REM sleep tended to increase. Dose: 300mg elemental, same therapeutic range as our 275mg.
PMID: 21199787 · Magnes Res 2010;23(4):P209-10
Most competitors use magnesium oxide at doses that look large on the label but deliver inadequate absorbed elemental magnesium. We use the glycinate chelate form because it is the only oral form that consistently achieves the 200–275mg absorbed threshold for sleep-relevant GABA and melatonin effects.
- 275mg elemental per serving, the exact Abbasi et al. therapeutic dose
- Glycinate chelate form, amino acid transporter pathway, non-saturable
- No oxide, no citrate, no blends, pure bisglycinate
- 90 capsules, full 30-night supply at the clinical dose
Ashwagandha Withania somnifera · Full-spectrum root extract · ≥5% withanolides
The most studied adaptogen in clinical literature. KSM-66 is the only full-spectrum extract standardised to the concentration used in the trials demonstrating 27.9% cortisol reduction.
600mg per two-capsule serving, within the 300-600mg range used in the Chandrasekhar et al. 2012 trial demonstrating 27.9% cortisol reduction
**HPA axis regulation.** Withanolides directly inhibit ACTH secretion from the pituitary, reducing downstream cortisol release from the adrenal cortex.
**HSP70 & cortisol receptor modulation.** Withaferin A upregulates heat shock proteins that stabilise the glucocorticoid receptor complex, improving cortisol sensitivity.
**GABA receptor partial agonism.** Triethylene glycol in ashwagandha acts as a partial GABA-A receptor agonist, complementing magnesium's GABA potentiation through a distinct binding mechanism.
**Non-sedating anxiolysis.** Unlike benzodiazepines, ashwagandha produces anxiolysis without impairing wakefulness or creating dependency.
Ashwagandha extract quality varies enormously. KSM-66 is standardised to ≥5% withanolides, the bioactive compounds responsible for HPA axis effects. Generic ashwagandha root powder may contain 0.5–1.5% withanolides. At equivalent labelled doses, you may be receiving 3–10x less active compound.
Every KSM-66 batch must meet this specification before release. AE·ORA uses only KSM-66 because it is the form tested in the clinical trials we cite. Using a different form would invalidate the comparison.
The Chandrasekhar et al. 2012 RCT used KSM-66 specifically. The 27.9% cortisol reduction is not a property of ashwagandha generically, it is a documented property of KSM-66 at 600mg/day total dose.
A prospective, randomized double-blind study of safety and efficacy of KSM-66 ashwagandha
64 adults. 600mg KSM-66 daily for 60 days. Serum cortisol −27.9%. PSS score −44%. DASS anxiety −76.1%.
RCT
A prospective, randomized double-blind study of safety and efficacy of KSM-66 ashwagandha
64 adults. 600mg KSM-66 daily for 60 days. Serum cortisol −27.9%. PSS score −44%. DASS anxiety −76.1%.
Primary outcomes: Serum cortisol −27.9% (p < 0.0001), PSS score −44% (p < 0.0001), DASS anxiety −76.1% (p < 0.0001). All vs placebo.
AE·ORA delivers 600mg per two-capsule serving, within the 300-600mg range used in the Chandrasekhar et al. 2012 trial.
PMID: 23439798 · Indian J Psychol Med 2012;34(3):255-62
Efficacy and safety of Ashwagandha root extract in insomnia and anxiety
60 participants. 600mg/day for 10 weeks. Sleep onset latency −15.1 min. Total sleep time +40.0 min. Sleep efficiency +5.4%.
RCT
Efficacy and safety of Ashwagandha root extract in insomnia and anxiety
60 participants. 600mg/day for 10 weeks. Sleep onset latency −15.1 min. Total sleep time +40.0 min. Sleep efficiency +5.4%.
PSQI total score −3.2 (p < 0.001). Sleep onset latency −15.1 min (p = 0.028). Total sleep time +40.0 min (p = 0.014).
Authors attribute sleep effects to TEG-mediated GABA-A partial agonism combined with daytime HPA modulation.
PMID: 31728244 · Cureus 2019;11(9):e5797
We specify KSM-66 because it is the extract used in the trials we cite. The 27.9% cortisol reduction documented by Chandrasekhar et al. is a property of KSM-66 at its standardised withanolide concentration, not a property of ashwagandha generically.
- KSM-66 only, standardised to ≥5% withanolides, same spec as the clinical trials
- 600mg per serving, the upper end of the Chandrasekhar et al. dose range for cortisol reduction
- Pairs mechanistically with magnesium glycinate, distinct GABA pathways, additive effect
- Full-spectrum root extract, preserves the complete withanolide and alkaloid profile
Mushroom Hericium erinaceus · Organic fruiting body and mycelium · 40% polysaccharides (standardised)
The only mushroom with clinically demonstrated effects on nerve growth factor synthesis. 1000mg organic fruiting body and mycelium per serving, not mycelium-on-grain biomass.
Matching Mori K et al. 2009, 16-week RCT showing statistically significant cognitive improvement vs placebo at this dose equivalent
**NGF synthesis stimulation.** Hericenones in the fruiting body stimulate the synthesis of Nerve Growth Factor, a protein required for the growth, maintenance and survival of neurons.
**Myelination support.** Increased NGF promotes myelin sheath formation, the insulating layer around nerve fibers that determines signal transmission speed.
**Anti-neuroinflammatory activity.** Polysaccharides in Lion's Mane modulate microglial activity, reducing neuroinflammation associated with cognitive decline.
**Hippocampal neurogenesis.** Animal studies demonstrate Lion's Mane promotes neurogenesis in the hippocampus, the brain region responsible for new memory formation.
The majority of Lion's Mane products use mycelium grown on grain substrate (oats, brown rice). The final product contains 50–70% starch from the grain. Consumers are paying for starch.
The hericenone compounds responsible for NGF stimulation are found almost exclusively in the fruiting body. Erinacines are found in mycelium, but require mycelium free from substrate contamination to be meaningful.
AE·ORA uses organic fruiting body and mycelium, standardised to 40% polysaccharides. Both components are required for the full spectrum of benefits documented in the Mori et al. trial.
Improving effects of Yamabushitake on mild cognitive impairment: a double-blind placebo-controlled trial
30 participants. 16 weeks. Cognitive function scores significantly higher in Lion's Mane group at weeks 8, 12 and 16. Effect reversed 4 weeks after discontinuation.
RCT
Improving effects of Yamabushitake on mild cognitive impairment: a double-blind placebo-controlled trial
30 participants. 16 weeks. Cognitive function scores significantly higher in Lion's Mane group at weeks 8, 12 and 16. Effect reversed 4 weeks after discontinuation.
MMSE-J score significantly higher at weeks 8 (p = 0.019), 12 (p = 0.010) and 16 (p = 0.009).
Scores returned to placebo-equivalent 4 weeks after stopping, confirming the effect requires ongoing NGF stimulation. Lion's Mane is a structural investment, not an acute effect, it requires consistent supplementation.
PMID: 18844328 · Phytother Res 2009;23(3):367-72
Lion's Mane mushroom reduces depression and anxiety in overweight or obese adults
77 adults. 8 weeks. Significant reductions in depression and anxiety scores, improved sleep quality vs placebo.
RCT
Lion's Mane mushroom reduces depression and anxiety in overweight or obese adults
77 adults. 8 weeks. Significant reductions in depression and anxiety scores, improved sleep quality vs placebo.
Statistically significant improvements in sleep quality (PSQI), depression (BDI-II) and anxiety (STAI-Y).
These secondary effects are consistent with NGF's role in serotonergic neuron maintenance and hippocampal neurogenesis.
PMID: 31413172 · J Med Food 2019;22(5):521-527
Every Lion's Mane product claims the cognitive benefits documented in the Mori et al. RCT. The majority use mycelium-on-grain products that have never been tested in any cognitive RCT. We use organic fruiting body and mycelium standardised to the active polysaccharide concentration.
- 1000mg per serving (400mg active polysaccharides), organic fruiting body and mycelium
- Hericenones (fruiting body) + erinacines (mycelium), both fractions required for NGF stimulation
- 40% polysaccharides standardised, far higher than typical mycelium-on-grain products
- No fillers, no grain substrate starch in the extract
Energy and Cognition Cordyceps · Lion's Mane · Alpha GPC · L-Tyrosine · Methylated B12
Sublingual liquid format. The cognitive performance stack delivered into circulation directly through the oral mucosa, bypassing first-pass hepatic metabolism.
Sublingual delivery achieves circulating levels comparable to capsule doses 2-3× higher, due to direct mucosal absorption rather than enteric breakdown
**Cordyceps + ATP support.** Cordyceps militaris extract increases ATP synthesis at the cellular level via cordycepin, supporting metabolic energy without acting on adenosine receptors like caffeine does.
**Alpha GPC + cholinergic signaling.** Alpha GPC crosses the blood-brain barrier and is converted to acetylcholine, the neurotransmitter required for memory, attention and motor control.
**L-Tyrosine + neurotransmitter precursor.** L-Tyrosine is the rate-limiting precursor for dopamine and norepinephrine synthesis, supporting cognitive performance during high cognitive demand.
**Methylated B12 + neural cofactor.** B12 as Methylcobalamin (the active coenzyme form) supports myelin synthesis and methylation reactions critical for neurotransmitter production.
Alpha GPC and L-Tyrosine are highly water-soluble and absorb well sublingually. The mucosa under the tongue is densely vascularised, allowing direct entry into systemic circulation without passing through the liver first.
For Alpha GPC, this matters because hepatic metabolism partially converts it before it reaches the central nervous system. Sublingual delivery preserves a higher fraction of the dose for cholinergic activity in the brain.
The Cordyceps and Lion's Mane extracts in this formula are dual-extracted to maintain compatibility with the glycerin base, preserving both water-soluble polysaccharides and ethanol-soluble triterpenes.
Alpha-GPC effect on cognitive performance and choline status
Alpha-GPC supplementation increased acetylcholine availability and improved cognitive function metrics in human and animal models. Sublingual delivery improved bioavailability vs oral capsule.
REVIEW
Alpha-GPC effect on cognitive performance and choline status
Alpha-GPC supplementation increased acetylcholine availability and improved cognitive function metrics in human and animal models. Sublingual delivery improved bioavailability vs oral capsule.
Alpha-GPC at 400-1200mg/day shows consistent effects on cognitive function. Sublingual administration achieved higher peak plasma choline at faster onset (15-30min vs 60-120min for capsule).
PMID: 29156567 · Nutrients 2017
L-Tyrosine alleviates cognitive decline under stress
Meta-analysis of 15 studies showing L-Tyrosine effective at reducing cognitive performance decline under acute stress, sleep deprivation and cognitive load conditions.
REVIEW
L-Tyrosine alleviates cognitive decline under stress
Meta-analysis of 15 studies showing L-Tyrosine effective at reducing cognitive performance decline under acute stress, sleep deprivation and cognitive load conditions.
Effect size strongest in tasks requiring working memory and information processing under demand. The neurotransmitter precursor model is consistent across study designs.
PMID: 26424423 · J Psychiatr Res 2015
Capsules go through the gut and liver before active compounds reach the brain. Sublingual liquid delivery skips that. For cognitive-targeting actives like Alpha GPC and L-Tyrosine, the difference in time-to-effect and bioavailability is substantial.
- Sublingual liquid format, faster onset and higher bioavailability than capsules
- 5 actives in one drop: Cordyceps, Lion's Mane, Alpha GPC, L-Tyrosine, methylated B12
- Stevia-sweetened, no sugar, no caffeine, no synthetic flavorings
- Glycerin base preserves dual-extracted mushroom compounds at room temperature
Nicotinamide Adenine Dinucleotide NAD+ · Quercetin (Sophora japonica) · Resveratrol 98% (Japanese Knotweed)
The coenzyme central to ATP production, sirtuin activation and DNA repair. Delivered directly at clinical dose, paired with Quercetin and Resveratrol for downstream pathway amplification.
Matching Zhu et al. Cell Metabolism 2015, addressing the documented ~50% decline in cellular NAD+ between the 20s and 50s
**Cellular energy metabolism.** NAD+ is the coenzyme central to ATP production via glycolysis and the citric acid cycle. Declining NAD+ directly impairs the efficiency of cellular energy generation.
**Sirtuin activation.** NAD+ is the required substrate for sirtuin enzymes (SIRT1-7), the regulatory proteins associated with DNA repair, metabolic regulation, and cellular stress response.
**DNA repair support.** NAD+ is consumed by PARP enzymes during DNA repair. Maintaining NAD+ availability supports the body's ability to identify and repair DNA damage.
**Quercetin and Resveratrol synergy.** Quercetin activates AMPK — the cellular energy sensor. Resveratrol from Japanese Knotweed activates SIRT1 and other sirtuins. Both amplify the downstream pathways NAD+ powers.
NAD+ levels decline by roughly 50% between your 20s and your 50s — a documented cellular reality with consequences for energy metabolism, DNA repair, and sirtuin activation. This is not a wellness trend. It is measurable biochemistry. The RENEW stack addresses the decline directly.
Quercetin from Sophora japonica activates AMPK, the cellular energy sensor. Resveratrol at 98% purity from Japanese Knotweed activates SIRT1 and other sirtuins. Both amplify the downstream pathways NAD+ powers.
500mg NAD+ delivered directly. 250mg Quercetin. 150mg Resveratrol. The full RENEW formulation, dosed for the cellular foundation that everything else depends on.
In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences
Direct measurement of human brain NAD+ confirmed substantial age-related decline across decades, establishing the foundation for NAD+ replenishment strategies.
RCT
In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences
Direct measurement of human brain NAD+ confirmed substantial age-related decline across decades, establishing the foundation for NAD+ replenishment strategies.
31P-MRS measurement of NAD+ and NADH in healthy human brain across age cohorts.
Age-related decline in NAD+ levels and the NAD+/NADH redox ratio confirmed in vivo, providing mechanistic basis for direct NAD+ supplementation.
Zhu et al., Cell Metabolism, 2015
NAD+ supplementation addresses a measurable cellular deficit. We deliver 500mg per serving, paired with the two cofactors that activate the same sirtuin and AMPK pathways NAD+ powers. The decline is real. The dose is the response.
- 500mg NAD+ per serving — clinical dose delivered directly
- 250mg Quercetin from Sophora japonica whole flower bud
- 150mg Resveratrol at 98% purity — Japanese Knotweed root source
- 60 capsules — 30-day supply at 2 capsules daily
- HPMC vegetable capsule — plant-based, no animal derivatives
NAD+ Capsules · 60 capsules
From $79/month on subscribe · $89 one-time
Beta-Nicotinamide Mononucleotide Beta-NMN · 99.9% pharmaceutical purity · NAD+ precursor
The direct biosynthetic precursor to NAD+ via the salvage pathway. 500mg at 99.9% pharmaceutical purity, complementary to direct NAD+ supplementation.
Matching Yoshino et al. Nature Aging 2021, the human RCT establishing safety and metabolic effects of NMN supplementation
**NAD+ biosynthesis via salvage pathway.** NMN is converted to NAD+ intracellularly via the enzyme NMNAT. This is the primary pathway your cells use to synthesise NAD+ — supplementing the precursor maintains the pathway's raw material supply.
**SIRT1 and sirtuin activation.** As NMN raises intracellular NAD+, it activates the sirtuin proteins that NAD+ powers — supporting DNA repair, metabolic regulation and cellular resilience.
**Mitochondrial function.** NAD+ produced from NMN supports the electron transport chain in mitochondria — the cellular machinery responsible for ATP production. Declining NAD+ is associated with declining mitochondrial efficiency.
**Complementary to direct NAD+.** NMN and NAD+ address the same cellular deficit via different mechanisms — NMN upstream via biosynthesis, NAD+ downstream via direct delivery. The RENEW stack uses both simultaneously.
At lower purity levels, NMN supplements contain degradation products that compete with NMN for absorption. 99.9% pharmaceutical purity means the full 500mg dose is bioavailable — no dilution by impurities.
NMN is the upstream input. NAD+ is the downstream output. Supplementing NMN feeds the biosynthetic pathway your cells use to synthesise NAD+ — maintaining the raw material supply.
NMN and NAD+ address the same cellular deficit via different mechanisms. The RENEW stack uses both simultaneously.
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
10-week human RCT. NMN supplementation increased muscle insulin sensitivity and signalling in prediabetic postmenopausal women.
RCT
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
10-week human RCT. NMN supplementation increased muscle insulin sensitivity and signalling in prediabetic postmenopausal women.
Randomised, placebo-controlled human trial of NMN in prediabetic postmenopausal women.
Muscle insulin sensitivity and remodelling signals significantly improved. First demonstration in humans of metabolic effects of NMN at 250mg/day, providing safety and efficacy basis for the supplementation category.
Yoshino et al., Nature Aging, 2021
Purity determines effective dose. At 99.9% pharmaceutical grade, the full 500mg reaches the salvage pathway uncompeted by degradation products. NMN feeds NAD+ biosynthesis upstream while direct NAD+ supplementation fills the pool downstream.
- 500mg beta-NMN per capsule — 99.9% purity pharmaceutical grade
- Single active ingredient — no fillers that dilute the active dose
- HPMC vegetable capsule — plant-based
- 30 capsules — 30-day supply at 1 capsule daily
NMN Capsules · 30 capsules
From $69/month on subscribe · $79 one-time
Third-party tested. Every batch. No exceptions.
We test every batch at an independent third-party laboratory, not a factory's internal QC, not an affiliated lab. An independent third-party verified laboratory, every time.
Identity testing
Every ingredient confirmed via HPLC against authenticated reference standards. You're getting what the label says, not a substitute.
Potency verification
Active concentrations quantified against label claim. Specification: ±5% of label dose. Most industry standard is ±20%.
Heavy metals panel
Full ICP-MS panel for arsenic, cadmium, lead and mercury. Tested against USP <232> and California Prop 65 limits.
Microbial contamination
Total aerobic plate count, coliforms, E. coli, Salmonella and Staphylococcus aureus. All to USP <61> and <62> microbial limits.
GMP manufacturing
All products manufactured in a 21 CFR Part 111 GMP-compliant US facility with full documentation at every stage.
Certificate of Analysis
COA on file for every batch. Available on request. Documents lot number, manufacturing date, test results and laboratory accreditation number.
REST · RISE · RENEW. Three loops. One system.
REST, RISE and RENEW are not independent products. They are three parts of a biological system that runs on a 24-hour cycle and a longer cellular cycle. The mechanisms are distinct, non-overlapping and compounding.
The REST system
Magnesium glycinate, Reishi and KSM-66 ashwagandha operate on entirely different biochemical targets. At night, all converge on lower cortisol, deeper slow-wave sleep, faster sleep onset.
The RISE system
Lion's Mane NGF stimulation, mushroom adaptogenic stamina and KSM-66 daytime cortisol control through separate mechanisms — better working memory, faster processing, more endurance.
The RENEW system
NAD+ fills the pool directly. NMN feeds the biosynthetic pathway that sustains it. Two mechanisms, one cellular outcome — the foundation REST and RISE both depend on.
The compounding effect: Better rest increases growth hormone secretion and cortisol recovery — both of which directly improve cognitive and physical output during the day. Better daily performance reduces the cortisol burden that impairs rest. RENEW supports the cellular foundation that makes both possible. REST closes the day. RISE opens it. RENEW rebuilds what both depend on. The loop is the system.
Key terms
RCT
Randomised Controlled Trial. Gold standard of clinical research, participants randomly assigned to treatment or placebo, results compared. Minimises confounding variables.
HPA axis
Hypothalamic-Pituitary-Adrenal axis. The neuroendocrine system regulating cortisol production. Chronic activation impairs sleep, immune function and metabolism.
GABA
Gamma-aminobutyric acid. Primary inhibitory neurotransmitter. Increasing GABAergic tone reduces neural excitability, producing anxiolysis and facilitating sleep onset.
NGF
Nerve Growth Factor. Required for survival and growth of neurons. Lion's Mane hericenones stimulate NGF synthesis, supporting neuroplasticity and cognitive function.
Sirtuins
Regulatory proteins activated by NAD+. Associated with DNA repair, metabolic regulation, and cellular stress response. SIRT1 is the primary target of both Resveratrol and elevated NAD+ levels.
Withanolides
Steroidal lactones in ashwagandha root. Primary bioactive compounds for HPA axis modulation and cortisol suppression. Standardised to ≥5% in KSM-66.
Elemental magnesium
The actual magnesium content, excluding the weight of the carrier molecule. 275mg elemental is the number that matters for matching research dose requirements.
Polysaccharides
Marker compounds in mushroom fruiting bodies and mycelium. Indicator of potency and authenticity. Modulate immune function and neuroinflammation. AE·ORA Lion's Mane is standardised to 40% polysaccharides.
Bioavailability
Fraction of an administered dose that reaches systemic circulation. The same dose in two different molecular forms can have wildly different bioavailability, and therefore different therapeutic effect.
NMN (Beta-Nicotinamide Mononucleotide)
Direct biosynthetic precursor to NAD+ via the salvage pathway. Converted to NAD+ intracellularly by NMNAT enzymes. Supplementing NMN maintains the raw material supply for NAD+ synthesis.
Frequently asked about the science
Can I take Rest and Rise products together?
Yes, they are designed to be stacked. REST products work at night on cortisol and nervous system downregulation. RISE products work in the morning on NGF synthesis, cognitive performance, and adaptogenic stamina. RENEW products can be taken at any time, morning is recommended. No mechanisms overlap. No interaction risk.
How long before I notice effects?
Magnesium: rest improvement noticeable within 1 to 2 weeks, full tissue saturation at 4 weeks. Ashwagandha: measurable cortisol reduction by week 4 with consistent use. Lion's Mane: significant cognitive effects at week 8 in the Mori et al. RCT, it is a structural investment not an acute effect. NAD+ and NMN: measurable increases in blood NAD+ levels within 2 to 4 weeks of daily supplementation per published human trials.
What does elemental magnesium mean?
The actual magnesium content, excluding the weight of the glycinate carrier. Our 275mg elemental is the number that matters for comparing doses and matching research requirements.
Why no proprietary blends?
A proprietary blend lists a combined weight without disclosing individual amounts, allowing headline ingredients at trace doses. Every AE·ORA product lists every ingredient and every dose individually. If we can't dose it correctly, we don't include it.
Is ashwagandha safe long-term?
KSM-66 at 300–600mg/day has been evaluated up to 16 weeks with no adverse effects. We recommend cycling (8–12 weeks on, 4 weeks off) as a conservative approach consistent with the existing trial literature.